Study: Nicotine Normalizes Schizophrenic Brain Activity

90 percent of schizophrenia patients smoke. Now scientists are figuring out why.

Almost 90 percent of people suffering from schizophrenia smoke cigarettes. That’s a smoking rate about six times higher than the general population. Scientists have long assumed that this is an example of self-medication.

Now a study in the journal Nature Medicine describes why those with schizophrenia smoke so much, and suggests that nicotine could be used to treat schizophrenia. The authors hope that in the future effective nicotine-based treatments will be available.

A genetic mutation called CHRNA5 is associated with cognitive problems in many schizophrenic patients. The new study shows how nicotine helps normalize brain activity in these people.

The researchers used a mouse model to show how nicotine affects cells in the prefrontal cortex of the brain, according to the study press release. They showed how nicotine “has a direct impact on the restoration of normal activity in nerve cells (neurons) involved in psychiatric disorders such as schizophrenia.”

The video above shows normal neuron activity in the prefrontal cortex of a control mouse from the study (left), and neuron activity in a mouse with the CHRNA5 mutation (right).

“These experimental results argue strongly that nicotine, or nicotinic agonists, could normalize [prefrontal cortex] activity and thus reduce some of the cognitive deficits found in humans with neuropsychiatric disorders,” says the paper.

The research team was led by Uwe Maskos of the Pasteur Institute in Paris, and included scientists from France, the United States, Germany, and Russia.

Research has long shown that nicotine has cognitive benefits for some users. Smokers are known to suffer less often than non-smokers from Alzheimer’s and Parkinson’s diseases, and that is likely to be from the nicotine in tobacco. And researchers are testing nicotine’s potential for treating people with ADHD and other cognitive issues.

This article first appeared here

 

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Sacramento County is considering banning flavored e-liquid, including the unincorporated areas !
Click link to see how you can save the flave.
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Wednesday, August 7th, 2019 at 9:20am
@mihotep Here's the story.
They say: It’s better than putting diesel in a car, says Edwards, because the constant running rate of the gennie uses the fuel more efficiently than idling and accelerating in a car.
I had thought of this. https://t.co/jaTwqLIM6w
Friday, August 2nd, 2019 at 10:43pm
@Biebert @KnowNicotine @JenniBiebertMKE When you point at someone, there are three fingers pointing back at you.
Friday, August 2nd, 2019 at 8:50am
Image is the data of who uses nicotine.
Take a gander at who we're denying alternatives to.
These are some of the reasons people use #nicotine, obviously.
There is an apparent link between nicotine and anti-psychosis. https://t.co/Nj3CTnmaoM
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Friday, August 2nd, 2019 at 8:31am
The PBS story was actually about a 'THC cartridge' that a teen had gotten from a random adult.
Re-labelled as 'Vaping puts teen in hospital', Aaron retweets it without investigation, saying 'ah HA look at THIS, u angry vapers!'... but no. You're insulting 1/2 of your supporters
Friday, August 2nd, 2019 at 8:31am
@KnowNicotine , if you devoted as much energy to anti-vaping rhetoric, and re-tweeting PBS and other coroporate LIES about vaping, towards truly knowing nicotine, I think we'd all appreciate it very much.
I'm not an 'angry vaper',don't think vaping is the only way,but please stop
Friday, August 2nd, 2019 at 8:13am
@KnowNicotine Ummmm
These are the only choices ?
You think nicotine addiction begins with vaping ?
Haven't you read the same facts we all read ?
This is not looking good for you @Biebert , really.
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We all wonder where your sudden anti-vaping agenda has come from https://t.co/Fd1UiaYkyF
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Friday, July 5th, 2019 at 11:15pm
@eaze Vaping is indeed the future.
Smoke has carbon, and is responsible for most lung problems resulting from combustion.
I suggest investing in a GOOD herb vape, at least $100-200 vape.
The others simply combust the herbs.
So many ppl dislike vaping bcuz they tried a bad device.
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(Thanks to Lightning on Disqus for this)
Yes, @Kelpalots, they do

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