Study: Nicotine Normalizes Schizophrenic Brain Activity

90 percent of schizophrenia patients smoke. Now scientists are figuring out why.

Almost 90 percent of people suffering from schizophrenia smoke cigarettes. That’s a smoking rate about six times higher than the general population. Scientists have long assumed that this is an example of self-medication.

Now a study in the journal Nature Medicine describes why those with schizophrenia smoke so much, and suggests that nicotine could be used to treat schizophrenia. The authors hope that in the future effective nicotine-based treatments will be available.

A genetic mutation called CHRNA5 is associated with cognitive problems in many schizophrenic patients. The new study shows how nicotine helps normalize brain activity in these people.

The researchers used a mouse model to show how nicotine affects cells in the prefrontal cortex of the brain, according to the study press release. They showed how nicotine “has a direct impact on the restoration of normal activity in nerve cells (neurons) involved in psychiatric disorders such as schizophrenia.”

The video above shows normal neuron activity in the prefrontal cortex of a control mouse from the study (left), and neuron activity in a mouse with the CHRNA5 mutation (right).

“These experimental results argue strongly that nicotine, or nicotinic agonists, could normalize [prefrontal cortex] activity and thus reduce some of the cognitive deficits found in humans with neuropsychiatric disorders,” says the paper.

The research team was led by Uwe Maskos of the Pasteur Institute in Paris, and included scientists from France, the United States, Germany, and Russia.

Research has long shown that nicotine has cognitive benefits for some users. Smokers are known to suffer less often than non-smokers from Alzheimer’s and Parkinson’s diseases, and that is likely to be from the nicotine in tobacco. And researchers are testing nicotine’s potential for treating people with ADHD and other cognitive issues.

This article first appeared here

 

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Thursday, May 23rd, 2019 at 7:56am
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Tuesday, May 14th, 2019 at 6:18am
@eJuicefairy @truthinitiative @KnowNicotine um....
nicotine is not the problem.
read more of this tweeter's thread to find out more about #nicotine .
it's about as harmful as coffee.
Tuesday, May 14th, 2019 at 6:16am
@KnowNicotine Yes, people are 'clueless', or rather, lied to by mainstream media.
I've seen outright LIES about vaping and e-liquid in mainstream media.
It's awful.
My liquid only has vegetable glycerin , nicotine (harmless as coffee basically), and FDA approved food flavors.
Shame on you, MSM
Friday, May 10th, 2019 at 6:47am
@SpiritWhirled @DylanSaccoccio ha ha.....
I've been telling people lately what a scam carbon taxes are.......
I'm not sure they'll even get this, but it's a discussion opener.
Thanx for the pic.
Tuesday, April 30th, 2019 at 12:14pm
@KnowNicotine The FDA just approved the 'IQOS' device.
The worst label they can use is 'may be addictive', because there ARE no other problems with nicotine.
Long-Term nicotine use has been approved with patches, gum, etc., with no known side effects, with correct dosage. @US_FDA

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